By Gail Skowron,Richard Ogden

ISBN-10: 1588296490

ISBN-13: 9781588296498

ISBN-10: 1617376957

ISBN-13: 9781617376955

A magisterial survey of all elements of the opposite transcriptase inhibitors (RTIs) used to regard HIV/AIDS, together with drug discovery, pharmacology, improvement of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our present realizing of the position of opposite transcriptase within the viral existence cycle, describe the invention and improvement of 8 nucleoside and nucleotide analogs that signify milestones in remedy background, and punctiliously speak about the query of toxicity and resistance to this classification of substances. in addition they deal with 3 non-nucleoside RTIs and their pharmacokinetics and comparative medical efficacy, new RTIs presently below improvement, and the influence of authorized brokers on therapy, generally, and on vertical transmission within the constructing world.

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Reverse Transcriptase Inhibitors in HIV/AIDS Therapy (Infectious Disease) by Gail Skowron,Richard Ogden


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